Dr. Michael Spiegel, M.D. Curriculum Vitae Dr. Michael Spiegel has conducted over 100 clinical research trials and has given over 100 lectures to physicians on the topic of arthritis and osteoporosis. He has appeared on national television including CNN and the Oxygen Network as well as local television to discuss various issues regarding the treatment of arthritis. As part of the Danbury Orthopedic Associates effort to provide our patients with a full range of musculoskeletal care Dr Spiegel bring over 17 years of both clinical and research experience in the field of Rheumatology and looks forward to many more years of practice. EMPLOYMENT: September 2006 - present Danbury Orthopedic Associates 1989 - August 2006 Arthritis Associates of CT/NY-LLC RESIDENCY AND INTERNSHIPS: 1987 Fellowship in Rheumatology: Brown University 1984-1985 Internal Medicine Intern: St. Francis Hospital & Medical Center 1987 Residency in Internal Medicine: St. Francis Hospital & Medical Center EDUCATION: 1980 Bachelor of Arts, State University of New York, Binghamton 1984 Medical Doctor, State University of New York, Downstate Medical Center, Brooklyn MEDICAL LICENSES: Connecticut License #027447 DEA Registration #BS1871842 New York State License #197459 HOSPITAL AFFILIATIONS: Attending: Danbury Hospital, Danbury, CT Attending: New Milford Hospital, New Milford, CT Consultant: Putnam Hospital, Putnam, NY PROFESSIONAL CERTIFICATION: Certified Clinical Investigator from February 2005 to February 2008 Diplomate, American Medical Association Diplomate, American Board of Internal Medicine Diplomate, National Board of Medical Examiners MEDICAL SOCIETY MEMBERSHIPS: American College of Rheumatology – Fellow Connecticut State Medical Society Fairfield County Medical Society December, 2001 – Nominated for inclusion in Best Doctors in America PUBLICATIONS: Agrawal, NM, Caldwell, J, Kivitz, AJ, Weaver, AL, Bocanegra,TS, Ball,J, Dhadda, S, Hurley, S, Hancock, L, Comparison of the Upper Gastro-intestinal Safety of Arthrotec 75 and Nabumetone in Osteoarthritis Patients at High Risk for Developing Nonsteroidal Anti- Inflammatory Drug-Induced Gatrointestinal Ulcers, Clinical Therapeutics Spiegel, Michael: Keeping Arthritis Patients Out of the Hospital, Managed Care Interface, Vol. II, 1998, Issue #6, pp. 81-85 Spiegel, Michael: Lyme Disease, Encarta Encyclopedia, 1997, 1999 Zimmerman, B., Spiegel, M., Lally, E.: Cryptococcal Meningitis and SLE, Seminars in Rheumatology, September, 1992 Ho, G., Spiegel, M., Schwartz, S.: Infectious Causes of Back Pain, 1990 PRESENTATIONS: Dinner Meetings for Merck Osteoporosis and Lilly Osteoporosis, Breakfast Meetings at Danbury Hospital for Osteoporosis Grand Rounds, Pathology Department of Danbury Hospital, Osteoporosis from Laboratory to bedside, October, 2004 Presentations of Osteoporosis to Eli Lilly & Co. and Merck, 2004 Grand Rounds, Danbury Hospital, Osteoporosis, June, 2003 Osteoporosis, Sound and Shore Hospital, September, 2003 Presentations on Osteoporosis, RA, OA for Lilly, Merck, Amgen, Proctor and Gamble, 2002-2003 Television Appearance: Interviewed on the Oxygen Network 10/2001 Johnson & Johnson, shareholder’s meeting, 2001 Presentations on Osteoporosis, Rheumatoid Arthritis, Osteoarthritis for Pharmacia, Lilly, Merck, Centocor, 2001 Interviewed by national publications such as Newsweek, Wall Street Journal, Redbook, Woman’s Day and the medical publication Internal Medicine Weekly, 2001 Consultant to Centocor on the use of Remicade in rheumatologist’s office, 2001 Use of Remicade in a Rheumatologist’s Office: Centocor Speaker Bureau, 2000 Presentations on NSAID Gastropathy, Sponsored by Merck, Pharmacia, 2000 Osteoporosis Presentations , Sponsored by Lilly, Merck, Proctor & Gamble, 2000 NSAID Gastropathy: Nyack Hospital, 10/99 Multiple presentations for Merck, Searle, Pfizer and Lilly, 1999 RA Update: CT Physician Assistant’s Annual State Meeting, 4/99 Osteopenia: Grand Rounds, Bridgeport Hospital, 2/99 Celebrex: Searle, Pfizer, 1999 NSAID Gastropathy, Searle, 1998 Lyme Disease, New Milford Hospital, June, 1998 Osteoporosis: Forum Lectures Sponsored by MERCK, April, June, November, December of 1996, 1997, 1998 Evista/Osteoporosis, Lilly, 1998 Case Presentations: Chest X-ray and Rheumatology, Danbury Hospital, May, 1998 Osteoporosis Overview, Breakfast with the Professor, Danbury Hospital, February, 1998 NSAID Gastropathy, Smith Kline, Danbury, CT and Norwalk, CT, 1997 Medical Management of Chronic Pain: Connecticut State Society of Physician Assistants, November, 1996 Evaluation of Lower Back Pain: Benedictine Hospital, Kingston, NY, October, 1996 Update on Lyme Disease: Westchester County Dermatological Society, June, 1996 Lyme Disease: Experimental Lyme Vaccine: New Milford Hospital, New Milford, CT, 1995 Viral Arthritis: Chief Discussant Grand Rounds, Danbury Hospital, Danbury, CT, 1994 Rash, Fever and Arthritis: Chief Discussant Grand Round, Danbury Hospital, Danbury, CT, 1994 Osteoarthritis in the Elderly: Tarrytown Hospital, Tarrytown, NY, 1993 Sarcoidosis and Arthritis: New Milford, CT, 1993 Differential Diagnosis of Arthritis: Sponsored by Searle Pharmaceutical Group, New York City, New Paltz, NY, New Milford, CT, 1993 Secondary Osteoarthritis: Hudson Valley Hospital, January, 1993 Toradol & Pain Management: Sponsored by Syntex Pharmaceutical Corp., Danbury, Medical Community, 1992 Osteoarthritis in the Elderly: Massachusetts Academy of Family Physicians, Newport, RI, 1992 Treatment of the Elderly with Arthritis: Connecticut State Medical Society, Meriden, CT, 1992 Vasculitis Update: Evaluation of the Acute Joint, Grand Rounds, New Milford Hospital, New Milford, CT, 1991 Clinical Manifestations of Inflammatory Muscle Disease: Grand Rounds, Department of Rheumatology, Brown University, 1989 Vasculitis Associated with Malignancy: Grand Rounds, Department of Rheumatology, Brown University, 1988 Two Patients with Cryptococccal Meningitis with SLE on Prednisone: Grand Rounds, Department of Rheumatology, Brown University, 1988 Chronic Monoarticular Arthropathy: Grand Rounds, Department of Rheumatology, Brown University, 1987 Acromegalic Arthropathy: Grand Rounds, Department of Rheumatology, Brown University, 1987 Hereditary Optic Atrophy: A Case Study of the K. Family: Grand Rounds, Department of Ophthalmology, Long Island Jewish Hospital, New Hyde Park, NY 1983 RESEARCH: Principal Investigator: A phase III, Multi-center, open label study to evaluate the efficacy, tolerability and safety of abatacept BMS-188667 in subjects with active rheumatoid arthritis on background non-bioligic DMARDs who have an inadequate response to anti-TNF therapy and have limited therapeutic options 2005 Dose response study of duloxetine versus placebo in the treatment of fibromyalgia syndrome2005 An 8-week, multi-center, randomized, double-blind, placebo-controlled, parallel group trial of Diclofenac Sodium Gel 1% in patients with primary osteoarthritis of the hand.2005 Comparison of the Effects of Teriparatide with those of Alendronate Sodium on Lumbar Spine Bone Mineral Density in Glucocorticoid-induced Osteoporosis.2004 Teraparatide(rDNA origin) Injection (LY333334) 2004 A Randomized, placebo-controlled, double-blind, multicenter study to evaluate the safety and efficacy of rituximab in combination with methotrexate in patients with active rheumatoid arthritis who have had an inadequate response to anti-TNFa therapies, 2004 A Randomized, Parallel-Group, Double-Blind study to evaluate the safety and efficacy of rofecoxib and celecoxib, in patients with osteoarthritis of the knee, 2003 A 13-week, multicenter, international, randomized, doubleblind, placebo-controlled,parallel-group study of COX189 200 mg o.d. in patients with rheumatoid arthritis using naproxen 500 mg b.i.d. as comparator, 2003 A Randomized, Double-Blind, Active-Comparator-Controlled, Parallel-Group Study to Evaluate the Safety of Etoricoxib in Patients with Osteoarthritis or Rheumatoid Arthritis, 2003 A Multicenter, Randomized, Double-Blind, Placebo controlled, 12-month study to evaluate the efficacy and safety of Oral Alendronate Sodium Once Weekly for the Prevention and Treatment of Glucocorticoid-Induced Bone Loss, 2002 A Randomized, Double-Blind, Double-Dummy, Parallel-Group, Multicenter Study to Evaluate and Compare the Effects of Once Weekly Alendronate and Risedronate on Bone Mineral Density in Postmenopausal Women with Ostioporosis,2002 A Randomized, Double-Blind Study to assess the Efficacy of Tacrolimus + Methotrexate vs. Placebo + Methotrexate in the Treatment of Rheumatoid Arthritis in Patients with partial response to Methotrexate, 2002 A Multicenter, Double-Blind, Randomized, Placebo-and Raloxifene-controlled study to assess safety and efficacy of TSE-424 in the prevention of postmenopausal osteoporosis, 2002 A Phase II Pivotal Trial of Oxypurinol for the Treatment of Symptomatic Hyperuricemic Patients Who are Unable to Tolerate Allopurinol, 2001 An Active-Comparator-and Placebo-Controlled, Parallel Group, Double-Blind, 52 Week Study to Assess the Safety and Efficacy of a COX II in rheumatoid Arthritis Patients, 2000 A Comparison of the Analgesic Efficacy and Safety of a Non Narcotic Analgesic Versus Placebo for the Treatment of a Painful Flare of Osteoarthritis, 2000 Non Narcotic Analgesic Open-Label, Extension Safety Trial in Patients with Chronic Pain, 1999 A 12-Week Study of Non Narcotic Analgesic Treatment for Patients with Osteoarthritis Pain, 1999 Clinical protocol to Evaluate the Long-Term Safety of COX II in Treating the Signs and Symptoms of Rheumatoid Arthritis, 1999 Double-Blind Placebo Controlled, Randomized Comparison Study of Efficacy and Upper Gastrointestinal Safety of a COX II and Naproxen 500 mg BID in treating Signs and Symptoms of Osteoarthritis of the Knee, 2000 Double-Blind Placebo Controlled, Randomized Comparison Study of Efficacy and Safety of a COX II and Naproxen 500mg in treating the signs and symptoms of Rheumatoid Arthritis, 2000 Placebo Controlled, Randomized, Dose-Ranging and Pilot Efficacy study of a COX II in Treating the Signs and Symptoms Of Rheumatoid Arthritis, 1997 Double-Blind Placebo Controlled, Comparative Study of the Efficacy and Safety of Arthrotec 75 BID, Nabumetone 1500 mg WD And Naproxen 500 mg BID in Treating the Signs and Symptoms of Osteoarthritis, 1997 A Multicenter, Double-Blind, Placebo Controlled, Randomized Comparison Study of the Efficacy and Upper Gastrointestinal Safety of a COX II and 500 mg Naproxen BID in treating the Signs and Symptoms of Rheumatoid Arthritis, 1997 Placebo-controlled, Double-blinded, Randomized Clinical Trial of Anti-TNF Chimeric Monoclonal Antibody (cA2) in Patients with Active Rheumatoid Arthritis Despite Methotrexame Treatment, 2 yrs.1997 A Multi-Center, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study to Investigate the Safety, Tolerability And Efficacy of A Novel Compound as Compared to Placebo, in the Treatment of Patients with mild to Moderate Osteoarthritis of the Knee, Over 3 Months, 1998 COX II Double Blind, Placebo Controlled, Randomized Comparison Study of Efficacy and Upper Gastrointestinal Safety in Treating the Signs and Symptoms of Osteoarthritis, 1996 COX II Drug Study: Double Blind Placebo Controlled, Randomized Comparison Study of Efficacy and Safety in Treating the Signs and Symptoms of Rheumatoid Arthritis, 1996 Sub-Investigator A phase III, randomized, double-blinded, placebo-controlled, multicenter study of retreatment with Rituximab in subjects with rheumatoid arthritis receiving background methotrexate.2006 A Phase III multicentre, double-blind, placebo-controlled, parallel group 52-week study to assess the efficacy and safety of 2 dose regimens of lyophilised CDP870 given subcutaneously as additional medication to methotrexate in the treatment of signs and symptoms and preventing structural damage in patients with active rheumatoid arthritis who have an incomplete response to methotrexate. 2005 A phase III multi-centre, open-label, follow-on study to CDP870-027, to assess the efficacy and safety of lyophilised CDP870 an engineered human anti-TNF PEG conjugae, dosed subcutaneously at 400 mg every two weeks as aditional medication to methotrexate, in the treatment of signs and symptoms and preventing structural damage in patients with active rheumatoid arthritis 2005 A Phase III Pivotal, Multi-center, Double-Blind, Randomized, Placebo-Controlled Monotherapy Study of Milnacipran for Treatment of Fibromyalgia 2005 An Extension Study of MLNMD02 for the Treatment of Fibromyalgia 2005 Double-blind, parallel-group, randomized, study of the efficacy and safety of continuous use of celecoxib vs the "usual use" of celecoxib in the treatment of subjects with chronic osteoarthritis of the hip or knee who require an anti-inflammatory medication for control of their pain 2005 A double-blind, randomized, placebo-controlled, multi-dose, phase III, parallel group study of tramadol ER for the management of moderate to moderately severe chronic pain of osteoarthritis of the hip and knee in adults.2005 A 13-week, randomized, double-blind, placebo-controlled, monotherapy trial of pregabalin (BID) in patients with fibromyalgia2004 A long term, open label, safety trial of pregabalin in patients with fibromyalgia.2004 A study to evaluate the efficacy of TDS-943 in the treatment of osteoarthritis of the knee.2004 A 52-week, international, multicenter, randomized, double-blind, double-dummy, parallel-group clinical trial to compare retention on treatment, safety, tolerability and efficacy of lumiracoxib 100 mg od, lumiracoxib 100mg bid and celecoxib 200mg od in patients with primary osteoarthritis of hip, knee, hand or spine2004 A Phase III Pivotal, Multi-center, Double-Blind, Randomized, Placebo-Controlled Mono-therapy Study of Milnacipran for Treatment of Fibromyalgia.2004 A three month study to evaluate the effect of Eszopiclone 3mg compared to placebo on daytime function in subjects with insomnia related to Rheumatoid Arthritis, 2004 A 13-week, multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel trial of 2 different dose regimens of lumiracoxib in patients with primary knee osteoarthritis, using celecoxib as a comparator, 2003 A 13-Week, Multicenter, international, randomized, double-blind, placebo-controlled, parallel-group study of COX189 in patients with rheumatoid arthritis using naproxen as comparator,2003 Double-Blind, Randomized, Dose-Ranging, Parallel-Group Comparison of the Efficacy and Safety of Extended Release Tramadol Hydrochloride Celecoxib and Placebo in the Treatment of Osteoarthritis of the Knee and/or Hip, 2002 A Multicenter, Double-Blind, Randomized Parallel-Group Trial to Compare the Efficacy and Safety of Three Doses of Meloxicam and Placebo in Patients with Rheumatoid Arthritis,2002 A Randomized, Double-Blind, Multicenter Study to Evaluate the Tolerability and Effectiveness of Etoricoxib vs. Diclofenac Sodium in Patients with Osteoarthritis, 2002 A double-blind, placebo controlled, randomized two week comparison study of the efficacy and tolerability of valdecoxib and rofecoxib in relieving the signs and symptoms of osteoarthritis of the knee, 2002 A 12-Week, randomized, double-blind, placebo-controlled, multicenter, parallel group study to investigate the efficacy and safety of ML3000 in patients with osteoarthritis of the knee, 2002 A double-blind, placebo-controlled, randomized comparison of the efficacy and safety of Celecoxib in treating the signs and symptoms of psoriatic arthritis, 2002 A double-blind, placebo-controlled, randomized six week comparison study of the efficacy of Valdecoxib and Rofecoxib in relieving the signs and symptoms of osteoarthritis of the knee. 2001 Double Blind, Placebo Controlled Parallel Group 12 week Trial to Assess the Efficacy and Safety of a Novel Compound in Patients with Chronic Low Back Pain, 2000 COX II Safety in Treated Hypertensive Patients with Osteoarthritis, 2000 A Randomized, Placebo Controlled Parallel Group Double Blind Study to Evaluate the Safety and Efficacy of COX II’s at Different Strengths in Patients with Osteoarthritis of the Knee or Hip,2000 A Multicenter, Randomized, Double Blind, Placebo Controlled Study of the Human Anti-TNF Monoclonal Antibody in Rheumatoid Arthritis Patients Currently Receiving Treatment with Methotrexate, 2000 Multicenter Randomized Double-Blind Placebo Controlled Study of the Safety of Human Anti-TNF Monoclonal Antibody in Patients with Active Rheumatoid Arthritis, 2000 Long Term Follow-Up of a Novel Compound, 2000 Multicenter, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of a Topical Plaster in the Treatment of Osteoarthritis of the Knee, 2000 Comparison of the Analgesic Efficacy and Safety of a Non Opioid Analgesic vs Placebo for the Treatment of a Painful Flare of Osteoarthritis, 2000 Clinical Protocol for a Double-blind, Randomized, Parallel Group comparison Study of the Safety of a COX II in Hypertensive Patients with Peripheral Osteoarthritis Taking Antihypertensive Medications, 1999 An Open, Multi-center Study to Evaluate the Safety and Immunogenicity of Booster Doses of LYMErix™ Lyme Disease Vaccine (Lipoprotein OspA) in Subjects Previously Receiving Immunization on a 0,1,12 month schedule in Lyme Studies 013 and 016, 1999 A Randomized, Double Blind, Multicenter Study to Evaluate the Tolerability and Effectiveness of a COX II. vs. Naproxen 500 mg b.i.d. in Patients with Osteoarthritis, 1999 A Double-Blind, Randomized, Stratified, Parallel-Group Study to Assess the Incidence of PUBs During Chronic Treatment with a COX II or Naproxen in patients With Rheumatoid Arthritis, 1999 A dose ranging, 24 week trial of a COX II in patients with primary knee osteoarthritis with or without hand osteoarthritis (followed by a 30 month extension), 1999 A double-blind, randomized, placebo controlled study to evaluate the safety and efficacy of a Unique Compound as an adjunct to background anti-rheumatoid therapy, in preventing structural joint damage in Rheumatoid Arthritis, 1999 COX II Drug Study Open Label: Long Term Safety in Treating The Signs and Symptoms of Osteoarthritis and Rheumatoid Arthritis, 1996 A usual Use, Open Label, Randomized, 3 Month Cohort, Outcomes Study in Osteoarthritis Pain Comparing OxyContin Vs.Oxycodone/APAP PRN, 1998 A Multicenter, Double-Blind, Double-Dummy, Randomized, Parallel-Group Trial to Compare the Efficacy and Safety of Three Doses of Meloxicam with Diclofenac and Placebo in Patients with Rheumatoid Arthritis, 1997 A Multicenter, Multinational Open-Label, 6-Month Extension Study of Oral Naloxone Comparing Continuous vs. Intermittent Treatment For Opioid-Induced Constipation in Patients with Chronic, Non-Malignant or Malignant Pain, 1997 A Multicenter, Double-Blind, Double-Dummy, Randomized Parallel-Group Trial to Compare the Efficacy and Safety of Three Doses of Meloxicam with Placebo in Patients with Osteoarthritis of the Knee or Hip; and Diclofenac as an Active Control to Assess Trial Sensitivity, 1998 Metalloproteinase inhibitor in the treatment of Osteoarthritis of the knee long term double blind, placebo controlled study. Phase II-III., 1998 A Multicenter, Double-Blind Study of an Opioid Antagonist in the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Malignant or Malignant Pain, 1997 A Multicenter, Double-Blind, Placebo Controlled Comparison Study of the Efficacy of a COX II in Treating the Signs and Symptoms of Osteoarthritis of the Knee, 1997 COX II Drug Study in Osteoarthritis: Double Blind, Placebo Controlled, Randomized Comparison Study of the Efficacy and Safety in Treating the Signs and Symptoms of Osteoarthritis, 1996 Double-Blind, Placebo Controlled, Randomized, Dose-Ranging and Pilot Efficacy Study of SC-65872 in Treating the Signs and Symptoms of Osteoarthritis of the Knee, 1997 A Double-Blind, Placebo Controlled, Randomized Comparison Study of the Efficacy and Safety of a COX II and Naproxen 500 mg BID in Treating the Signs and Symptoms of Osteoarthritis of the Hip, 1997 Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of ULTRAM in Subjects with Pain of Fibromyalgia, 1996 Fibromyalgia Study, 1996 Lyme Vaccine Clinical Safety and Efficacy Trial Study with 500 Subjects, 1995-1996 Lyme Vaccine Follow-Up Immunologic and Safety Study, 1996 Double-Blind Placebo Controlled, Comparative Study of the Efficacy and Safety of Arthrotec 75 BID, Nabumetone 1500 mg WD And Naproxen 500 mg BID in Treating the Signs and Symptoms of Osteoarthritis, 1997 Double Blind, Placebo Controlled study to evaluate the safety and efficacy of a metalloproteinase inhibitor in Rheumatoid Arthritis, Ongoing, 1998 Investigator: Biomagetic Therapy and Osteoarthritis, 1991 Public Health Research: The Patient as a Consumer, 1981 Research Assistant: Department of Environmental Medicine, State University Of New York, Downstate Medical Center, 1981-1982   Physicians Dr. Brand Dr. Craig Dr. Deveney Dr. DiGiovanni Dr. Foster Dr. Henshaw Dr. Hermantin Dr. LaGratta Dr. Sealey Dr. Southern Dr. Spiegel Dr. Tietjen